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Glyceraldehyde-3-phosphate dehydrogenase also known as (GAPDH) catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD), an important energy-yielding step in carbohydrate metabolism. Recent evidence suggests that it also is involved in a number of cellular processes such as membrane fusion, phosphotransferase activity, DNA replication and repair, and nuclear RNA export. GAPDH has also been implicated in playing a role in different pathologies such as cancer progression, apoptosis, and neuronal diseases such as Alzheimer’s and Huntington’s disease. GAPDH is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.

 Imgenex Corp develops and commercializes novel reagents for the scientific study of human biology and disease and for the production of new diagnostic assays and potential therapies of such diseases.  One of these reagents is the housekeeping antibody GAPDH.  GAPDH is used widely as a loading control by measuring protein quantification. 

 Imgenex has built an outstanding reputation for delivering quality antibodies to many world class institutions.  Publications released from these institutions and other independent researchers have validated the effectiveness of Imgenex housekeeping antibodies.  Also note that Imgenex has goat polyclonal, rabbit polyclonal, mouse polyclonal options for GAPDH. 

 To see the many publications citing imgenex GAPDH please go to www.imgenex.com and look at the GAPDH options. 

See also: tubulin, actin, histone, tissue lysate, tumor lysate, glycolytic enzymes western blot, tissue microarray, loading control

www.Imgenex.com

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About the Author:
Imgenex Corp. develops and commercializes novel reagents for the scientific study of human biology and disease and for the production of new diagnostic assays and potential therapies of such diseases. These novel reagents include antibodies, gene and protein expression systems, and arrays of various cells and tissues for use in studies of functional genomics. Areas of biological interest at IMGENEX include cancer, apoptosis (programmed cell death), molecular signaling pathways, cellular aging, and metabolic and infectious diseases. Our corporate office is located in Sorrento Valley, in close proximity to the University of California at San Diego, The Salk Institute and The Scripps Research Institute.
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